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Bye Bye Fever is a brand by Hisamitsu Pharmaceutical Co, a Japanese pharmaceutical company headquartered in Saga and Tokyo. Hisamitsu is a well known company that specialized in transdermal drug delivery system technology since the introduction of its original line of patches back in 1903. Bye Bye Fever brand is famously known by many users across the countries as it provides cooling gel sheet product that lasts up to 10 hours to provide effective relief for fever.